PROFILE
UPM's Staff Profile
PROF. MADYA DR. CHIA SUET LIN
KETUA LABORATORI
FACULTY OF BIOTECHNOLOGY AND BIOMOLECULAR SCIENCES
PROFESSIONAL
Dr. Eddie Chia obtained his BSc (Microbiology), MSc (Molecular Biology), and PhD (Medical Biotechnology) from Universiti Putra Malaysia. Currently, he is the head of laboratory for UPM-MAKNA Cancer Research Laboratory (CANRES), Institute of Bioscience, and also an Associate Professor in the Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia. His research interest is in field of virology, specifically, Newcastle disease virus (NDV), as an oncolytic virus for the treatment of cancer. His research team is working on genetically modifying the virus to reduce its pathogenicity towards avian species and to enhance the oncolytic activities of the virus by inserting potential gene(s) into the viral genome.
NAME :
(Prof. Madya Dr.) Chia Suet Lin
POSITION :
Ketua Laboratori
ENTITY :
Faculty Of Biotechnology And Biomolecular Sciences
DOWNLOAD CURRICULUM VITAE (PDF)
EDUCATIONAL BACKGROUND
2012
Doctor of Philosophy (Medical Biotechnology)
2005
Master of Science (Molecular Biology)
2002
Bachelor of Science (Honours) Microbiology
1999
Diploma in Laboratory Technology
WORKING EXPERIENCE
2012
Senior Lecturer - Universiti Putra Malaysia
2004
Lecturer - Tunku Abdul Rahman college
PROJECT
2017
Translational development of oncolytic Newcastle Disease Virus for treatment of colorectal cancer
2015
Enhancing the therapeutic potential of rAF NDV cancer vaccine
2015
Mechanism of methicillin resistant Staphylococcus aureus biofilms degradation by phage display
2015
Rescue of a genetic engineered lentogenic NDV vaccine with enhanced immunogenic properties
2014
Investigating the behaviour of Lactococcus lactis M4 during interaction with human colon cancer cell line, SW620
2014
Developing a Nanoparticulate-Delivery System for Increased Therapeutic Delivery of Anticancer Drugs using Fluorescently Labelled Chitosan Nanoparticles
2014
Development of Nanodelivery Systems for Anti-Cancer Drugs
2013
Detection of Persistent Newcastle disease virus Infection in Various Cancer Cell Lines
2013
Global Transcriptomic Analysis of Colorectal Cancer Cells Persistently Infected with Newcastle Disease Virus
CONSULTANCY SERVICES
2016
Isolation and Identification of unknown bacteria from POME
COURSE ATTENDED
2016
Good Clinical Practice
RESEARCH AREA
Virology, Microbiology, Medical Biotechnology, Cancer Biology, Cancer virotherapy
PUBLICATION
Published Journal:
1. Leong SW, Chia SL, Abas F, and Yusoff K. 2020. Synthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer. Bioorganic & Medicinal Chemistry Letters 30: 127065.
https://doi.org/10.1016/j.bmcl.2020.127065
2. Yusof NA, Leong SW, Chia SL, Harun SN, Abdul Rahman MB, Vallis KA, Gill MR, and Ahmad H. 2020. Metallointercalator [Ru(dppz)2(PIP)]2+ Renders BRCA Wild-Type Triple-Negative Breast Cancer Cells Hypersensitive to PARP Inhibition. ACS Chemical Biology 15(2): 378-387.
3. Cheow P-S, Tan TK, Song AAL, Yuosff K. Chia SL. 2020. An improved method for the rescue of recombinant Newcastle disease virus. Biotechniques 68(2): 96-100.
4. Mohamed Amin A, Che Ani MA, Tan SW, Yeap SK, Alitheen NB, Syed Najmuddin SUF, Kalyanasundram J, Chan SC, Veerakumarasivam A, Chia SL, Yusoff K. 2019. Evaluation of a Recombinant Newcastle disease virus expressing Human IL12 against Human Breast Cancer. Scientific Reports 9: 13999.
DOI: 10.1038/s41598-019-50222-z
5. Lee CL, Veeramani S, Molouki A, Lim SHE, Thomas W, Chia SL, and Yusoff K. 2019. Virotherapy: Current Trends and Future Prospects for Treatment of Colon and Rectal Malignancies. Cancer Investigation 37(8): 393 – 414.
DOI:10.1080/07357907.2019.1660887
6. Tham ML, Yusoff K, Othman S. and Chia SL. 2019. V protein, the virulence factor across the family Paramyxoviridae: a review. Asia Pacific Journal of Molecular Biology and Biotechnology 27(3): 73-84.
7. Dyer A, Baugh R, Chia SL, Frost S, Iris, Jacobus EJ, Khalique H, Pokrovska TD, Scott EM, Taverner WK, Seymour LW, Lei J. 2019. Turning cold tumours hot: oncolytic virotherapy gets up close and personal with other therapeutics at the 11th Oncolytic Virus Conference. Cancer Gene Therapy 26: 59-73.
https://doi.org/10.1038/s41417-018-0042-1
8. Faroque H, Lau YS, Yong CX, Abdul Rahim R, Chia SL, Othman S. 2018. Bactofection of SW620 cell by Lactococcus lactis M4. Asia Pacific Journal of Molecular Biology and Biotechnology 26(1): 29-41.
9. Faudzi H, Faroque H, Chia SL, Abdul Rahim R, Othman S. 2018. Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies. Asia Pacific Journal of Molecular Biology and Biotechnology 26(1): 1-10.
10. Leong SW, Chia SL, Abas F, Yusoff K. 2018. Asymmetrical meta-methoxylated diarylpentanoids: Rational design, synthesis and anti-cancer evaluation in-vitro. European Journal of Medicinal Chemistry 157: 716-718.
11. Kalyanasundram J, Hamid A, Yusoff K, Chia SL. 2018. Newcastle disease virus strain AF2240 as an oncolytic virus: A review. Acta Tropica 183: 126-133.
12. Chia SL, Lei J, Ferguson DJP, Dyer A, Fisher KD, Seymour LW. 2017. Group B Adenovirus Enadenotucirev Infects Polarised Colorectal Cancer Cells Efficiently from the Basolateral Surface Expected to be Encountered during Intravenous Delivery to Treat Disseminated Cancer. Virology 505: 162-171.
13. Dyer A, Di Y, Calderon H, Illingworth S, Kueberuwa G, Tedcastle A, Jakeman P, Chia SL, Brown A, Silva MA, Barlow D, Beadle J, Hermiston T, Ferguson DJP, Champion B, Fisher KD, Seymour LW. 2017. Oncolytic group B adenovirus Enadenotucirev mediates non-apoptotic cell death with membrane disruption and release of inflammatory mediators. Molecular Therapy Oncolytics 4: 18-30.
14. Chia SL. 2016. Viruses as a cure for cancer? Scientific Malaysian Magazine 12: 8-11.
15. Kalyanasundram J, Chia SL, Song AAL, Raha AR, Young HA, Yusoff K. 2015. Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis. BMC Biotechnology 15(1):113.
16. Khoso FN, Wong SK, Chia SL, Lau WH. 2015. Molecular Identification of Synanthropic Flies in Malaysia. Australian Journal of Basic and Applied Sciences 9(5):390-396.
17. Khoso FN, Wong SK, Chia SL, Lau WH. 2015. Assessment of non-biting synanthropic flies associated with fresh markets. Journal of Entomology and Zoology Studies 3(1): 13-20.
18. Chia SL, Yusoff K, Shafee N. 2014. Viral persistence in colorectal cancer cells infected by Newcastle disease virus. Virology J. 11 (1): 91.
19. Chia SL, Tan WS, Yusoff K, Shafee N. 2012. Plaque formation by a velogenic Newcastle disease virus in human colorectal cancer cell lines. Acta Virologica 56: 345-347.
20. Chia SL, Tan WS, Shaari K, Abdul Rahman N, Yusoff K, Satyanarayanajois SD. 2006. Structural analysis of peptides that interact with Newcastle disease virus. Peptides 27(6): 1217-25.
Patent:
1. Reverse genetics system to provide recombinant viscerotropic virulent genotype VIII Newcastle disease virus (NDV) strain AF2240-I (rAF). Malaysian Patent Application no: PI2017701829
2. Recombinant Newcastle disease virus as an oncolytic agent. Malaysia Patent Application no: PI2019006518
Book:
1. Newcastle disease virus colloquium 2009 (ISBN 978-967-344-077-1)
Member of the editorial board
Book Chapter:
1. Yasmin AR, Chia SL, Looi QH, Omar AR, Noordin MM, and Ideris A. 2019. Herbal extracts as antiviral agents. In Feed Additives 1st Edition Aromatic Plants and Herbs in Animal Nutrition and Health. Ed. Florou-Paneri P, Christaki E, Giannenas I. Elsevier: Academic Press. Pg 115-132. (ISBN: 9780128147009; ebook ISBN: 9780128147016)
Other publication:
1. Khoso, F.N., Wong, S.K., Chia, S.L. and Lau, W.H. 2013. Cytochrome oxidase subunit I (COI) gene sequences of 17 local flies submitted and published in GenBank. Accession no. KC855270 – KC855286.
1. Leong SW, Chia SL, Abas F, and Yusoff K. 2020. Synthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer. Bioorganic & Medicinal Chemistry Letters 30: 127065.
https://doi.org/10.1016/j.bmcl.2020.127065
2. Yusof NA, Leong SW, Chia SL, Harun SN, Abdul Rahman MB, Vallis KA, Gill MR, and Ahmad H. 2020. Metallointercalator [Ru(dppz)2(PIP)]2+ Renders BRCA Wild-Type Triple-Negative Breast Cancer Cells Hypersensitive to PARP Inhibition. ACS Chemical Biology 15(2): 378-387.
3. Cheow P-S, Tan TK, Song AAL, Yuosff K. Chia SL. 2020. An improved method for the rescue of recombinant Newcastle disease virus. Biotechniques 68(2): 96-100.
4. Mohamed Amin A, Che Ani MA, Tan SW, Yeap SK, Alitheen NB, Syed Najmuddin SUF, Kalyanasundram J, Chan SC, Veerakumarasivam A, Chia SL, Yusoff K. 2019. Evaluation of a Recombinant Newcastle disease virus expressing Human IL12 against Human Breast Cancer. Scientific Reports 9: 13999.
DOI: 10.1038/s41598-019-50222-z
5. Lee CL, Veeramani S, Molouki A, Lim SHE, Thomas W, Chia SL, and Yusoff K. 2019. Virotherapy: Current Trends and Future Prospects for Treatment of Colon and Rectal Malignancies. Cancer Investigation 37(8): 393 – 414.
DOI:10.1080/07357907.2019.1660887
6. Tham ML, Yusoff K, Othman S. and Chia SL. 2019. V protein, the virulence factor across the family Paramyxoviridae: a review. Asia Pacific Journal of Molecular Biology and Biotechnology 27(3): 73-84.
7. Dyer A, Baugh R, Chia SL, Frost S, Iris, Jacobus EJ, Khalique H, Pokrovska TD, Scott EM, Taverner WK, Seymour LW, Lei J. 2019. Turning cold tumours hot: oncolytic virotherapy gets up close and personal with other therapeutics at the 11th Oncolytic Virus Conference. Cancer Gene Therapy 26: 59-73.
https://doi.org/10.1038/s41417-018-0042-1
8. Faroque H, Lau YS, Yong CX, Abdul Rahim R, Chia SL, Othman S. 2018. Bactofection of SW620 cell by Lactococcus lactis M4. Asia Pacific Journal of Molecular Biology and Biotechnology 26(1): 29-41.
9. Faudzi H, Faroque H, Chia SL, Abdul Rahim R, Othman S. 2018. Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies. Asia Pacific Journal of Molecular Biology and Biotechnology 26(1): 1-10.
10. Leong SW, Chia SL, Abas F, Yusoff K. 2018. Asymmetrical meta-methoxylated diarylpentanoids: Rational design, synthesis and anti-cancer evaluation in-vitro. European Journal of Medicinal Chemistry 157: 716-718.
11. Kalyanasundram J, Hamid A, Yusoff K, Chia SL. 2018. Newcastle disease virus strain AF2240 as an oncolytic virus: A review. Acta Tropica 183: 126-133.
12. Chia SL, Lei J, Ferguson DJP, Dyer A, Fisher KD, Seymour LW. 2017. Group B Adenovirus Enadenotucirev Infects Polarised Colorectal Cancer Cells Efficiently from the Basolateral Surface Expected to be Encountered during Intravenous Delivery to Treat Disseminated Cancer. Virology 505: 162-171.
13. Dyer A, Di Y, Calderon H, Illingworth S, Kueberuwa G, Tedcastle A, Jakeman P, Chia SL, Brown A, Silva MA, Barlow D, Beadle J, Hermiston T, Ferguson DJP, Champion B, Fisher KD, Seymour LW. 2017. Oncolytic group B adenovirus Enadenotucirev mediates non-apoptotic cell death with membrane disruption and release of inflammatory mediators. Molecular Therapy Oncolytics 4: 18-30.
14. Chia SL. 2016. Viruses as a cure for cancer? Scientific Malaysian Magazine 12: 8-11.
15. Kalyanasundram J, Chia SL, Song AAL, Raha AR, Young HA, Yusoff K. 2015. Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis. BMC Biotechnology 15(1):113.
16. Khoso FN, Wong SK, Chia SL, Lau WH. 2015. Molecular Identification of Synanthropic Flies in Malaysia. Australian Journal of Basic and Applied Sciences 9(5):390-396.
17. Khoso FN, Wong SK, Chia SL, Lau WH. 2015. Assessment of non-biting synanthropic flies associated with fresh markets. Journal of Entomology and Zoology Studies 3(1): 13-20.
18. Chia SL, Yusoff K, Shafee N. 2014. Viral persistence in colorectal cancer cells infected by Newcastle disease virus. Virology J. 11 (1): 91.
19. Chia SL, Tan WS, Yusoff K, Shafee N. 2012. Plaque formation by a velogenic Newcastle disease virus in human colorectal cancer cell lines. Acta Virologica 56: 345-347.
20. Chia SL, Tan WS, Shaari K, Abdul Rahman N, Yusoff K, Satyanarayanajois SD. 2006. Structural analysis of peptides that interact with Newcastle disease virus. Peptides 27(6): 1217-25.
Patent:
1. Reverse genetics system to provide recombinant viscerotropic virulent genotype VIII Newcastle disease virus (NDV) strain AF2240-I (rAF). Malaysian Patent Application no: PI2017701829
2. Recombinant Newcastle disease virus as an oncolytic agent. Malaysia Patent Application no: PI2019006518
Book:
1. Newcastle disease virus colloquium 2009 (ISBN 978-967-344-077-1)
Member of the editorial board
Book Chapter:
1. Yasmin AR, Chia SL, Looi QH, Omar AR, Noordin MM, and Ideris A. 2019. Herbal extracts as antiviral agents. In Feed Additives 1st Edition Aromatic Plants and Herbs in Animal Nutrition and Health. Ed. Florou-Paneri P, Christaki E, Giannenas I. Elsevier: Academic Press. Pg 115-132. (ISBN: 9780128147009; ebook ISBN: 9780128147016)
Other publication:
1. Khoso, F.N., Wong, S.K., Chia, S.L. and Lau, W.H. 2013. Cytochrome oxidase subunit I (COI) gene sequences of 17 local flies submitted and published in GenBank. Accession no. KC855270 – KC855286.