A
PROFILE
UPM's Staff Profile
PROF. MADYA DR. NORMI BINTI MOHD YAHAYA
KETUA JABATAN
FACULTY OF BIOTECHNOLOGY AND BIOMOLECULAR SCIENCES
normi_yahaya
BM
EN

PROFESSIONAL

Associate Professor at the Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences
NAME :
(Prof. Madya Dr.) Normi Binti Mohd Yahaya
POSITION :
Ketua Jabatan
ENTITY :
Faculty Of Biotechnology And Biomolecular Sciences

TEACHING
BSM3204 Principles of Genetics
BSM4601 Protein Engineering
BSM3101 Cell and Developmental Biology
BSM4603 STRUCTURAL BIOLOGY
COMMITTEE
2019
Head of Industry and Community Committee
2016
Executive Committee of Young Scientists Network-Academy of Sciences Malaysia (Chair of Science Communication)
2015
Executive Committee of Young Scientists Network-Academy of Sciences Malaysia (Chair of APEC Science Communication)
2014
Co-chair APEC Young Scientists Workshop on Effective Science Communication in the 21st Century - Sept 2014 – Sept 2015
2011
Chair of Committee for Department Promotional Program
2011
Jawatankuasa Penyelidikan dan Pengajian
Siswazah
2007
Internal expert group member for Penang
Biosatellite Project: “Strategic Roadmap for the Development of Biopharmaceutical Research & Industry in the Northern Region of Peninsular Malaysia”
2007
Facilitator for Promotion of Biotechnology
Program at Government Schools
AWARD AND ACHIEVEMENT
2022
Kurita Water and Environment Foundation
2015
Excellent Service Award, Univerisiti Putra Malaysia
2015
L’Oreal-UNESCO for Women in Science Fellowship
2015
Malaysian delegate to the APEC 6th Policy Partnership on Science, Technology and Innovation (PPSTI) Meeting, Manila, Philippines, 2015 for APEC Virtual Science Media Center proposal presentation
2015
Co-project overseer, together with the Academy of Sciences Malaysia, on the project APEC Young Scientists Workshop on Effective Science Communication in the 21st Century (APEC PPSTI funded project worth USD 130,000.00)
2013
Young Scholar Award 44th IUPAC World Chemistry Congress
2010
Selected Young Scientist for the 60th Meeting of Nobel Prize Winners with Young Scientists In Lindau, Germany
2010
American Chemical Society PACIFICHEM Young Scholar Award
2009
Malaysian Toray Science Foundation
2007
Internal expert group member for Penang Biosatellite Project: “Strategic Roadmap for the Development of Biopharmaceutical Research & Industry in the Northern Region of Peninsular Malaysia”
AREA OF SPECIALISATION
Molecular Biology
Structural Biology
Protein Biochemistry
RESEARCH AREA
Microbial Protein Structure and Function
Protein and Peptide Engineering
RESEARCH INTEREST
Enzyme engineering
Peptide inhibitor design and characterization
Protein structure and function
PUBLICATION
Au, S. X., Mohd Padzil, A., Muhd Noor, N. D., Matsumura, H., Raja Abdul Rahman, R. N. Z., & Normi, Y. M. (2023). Probing the substrate binding modes and catalytic mechanisms of BLEG-1, a promiscuous B3 metallo-β-lactamase with glyoxalase II properties. PloS one, 18(9), e0291012.

Puan, S. L., Erriah, P., Baharudin, M. M. A., Yahaya, N. M., Kamil, W. N. I. W. A., Ali, M. S. M., Ahmad, S. A., Oslan, S. N., Lim, S., & Sabri, S. (2023). Antimicrobial peptides from Bacillus spp. and strategies to enhance their yield. Applied microbiology and biotechnology, 107(18), 5569–5593.

Alias, F. L., Nezhad, N. G., Normi, Y. M., Ali, M. S. M., Budiman, C., & Leow, T. C. (2023). Recent Advances in Overexpression of Functional Recombinant Lipases. Molecular biotechnology, 10.1007/s12033-023-00725-y.

Nezhad, N.G., Rahman, R.N.Z.R.A., Normi, Y.M. et al. Isolation, screening and molecular characterization of phytase-producing microorganisms to discover the novel phytase. Biologia 78, 2527–2537.

Abdul Aziz, S. F. N., Rahim, A. S. M. A., Normi, Y. M., Alang Ahmad, S. A., & Salleh, A. B. (2023). Rational design of mini protein mimicking uricase: Encapsulation in ZIF-8 for uric acid detection. Proteins, 91(7), 967–979.

Hamdan, S. H., Maiangwa, J., Nezhad, N. G., Ali, M. S. M., Normi, Y. M., Shariff, F. M., Rahman, R. N. Z. R. A., & Leow, T. C. (2023). Knotting terminal ends of mutant T1 lipase with disulfide bond improved structure rigidity and stability. Applied microbiology and biotechnology, 107(5-6), 1673–1686.

Nezhad, N. G., Rahman, R. N. Z. R. A., Normi, Y. M., Oslan, S. N., Shariff, F. M., & Leow, T. C. (2023). Recent advances in simultaneous thermostability-activity improvement of industrial enzymes through structure modification. International journal of biological macromolecules, 232, 123440.

Khairul Anuar, N. F. S., Huyop, F., Ur-Rehman, G., Abdullah, F., Normi, Y. M., Sabullah, M. K., & Abdul Wahab, R. (2022). An Overview into Polyethylene Terephthalate (PET) Hydrolases and Efforts in Tailoring Enzymes for Improved Plastic Degradation. International journal of molecular sciences, 23(20), 12644.

Nezhad, N. G., Rahman, R. N. Z. R. A., Normi, Y. M., Oslan, S. N., Shariff, F. M., & Leow, T. C. (2022). Thermostability engineering of industrial enzymes through structure modification. Applied microbiology and biotechnology, 106(13-16), 4845–4866.

Abdul Aziz, S. F. N., Salleh, A. B., Ashari, S. E., Normi, Y. M., Yusof, N. A., & Alang Ahmad, S. A. (2022). Designed Mini Protein 20 Mimicking Uricase Encapsulated in ZIF-8 as Nanozyme Biosensor for Uric Acid Detection. Nanomaterials, 12(13), 2290.

Yahaya, R. S. R., Phang, L. Y., Normi, Y. M., Abdullah, J. O., Ahmad, S. A., & Sabri, S. (2022). Feather-Degrading Bacillus cereus HD1: Genomic Analysis and Its Optimization for Keratinase Production and Feather Degradation. Current microbiology, 79(6), 166.

Chin, J. H., Samian, M. R., & Normi, Y. M. (2022). Characterization of polyhydroxyalkanoate production capacity, composition and weight synthesized by Burkholderia cepacia JC-1 from various carbon sources. Heliyon, 8(3), e09174.

Au, S. X., Noor, N. D. M., Matsumura, H., Rahman, R. N. Z. R. A., & Normi, Y. M. (2022). Procedure of the overexpression, purification and crystallization of BLEG-1, a bifunctional and evolutionary divergent B3 metallo-β-lactamase, for structure-function studies. MethodsX, 9, 101740.

Hamdan, S. H., Maiangwa, J., Ali, M. S. M., Normi, Y. M., Sabri, S., & Leow, T. C. (2021). Thermostable lipases and their dynamics of improved enzymatic properties. Applied microbiology and biotechnology, 105(19), 7069–7094.

Au, S. X., Dzulkifly, N. S., Muhd Noor, N. D., Matsumura, H., Raja Abdul Rahman, R. N. Z., & Normi, Y. M. (2021). Dual Activity BLEG-1 from Bacillus lehensis G1 Revealed Structural Resemblance to B3 Metallo-β-Lactamase and Glyoxalase II: An Insight into Its Enzyme Promiscuity and Evolutionary Divergence. International journal of molecular sciences, 22(17), 9377.

Yahaya, R. S. R., Normi, Y. M., Phang, L. Y., Ahmad, S. A., Abdullah, J. O., & Sabri, S. (2021). Molecular strategies to increase keratinase production in heterologous expression systems for industrial applications. Applied microbiology and biotechnology, 105(10), 3955–3969.

Selvaraju, G., Leow, T. C., Salleh, A. B., & Normi, Y. M. (2020). Design and Characterisation of Inhibitory Peptides against Bleg1_2478, an Evolutionary Divergent B3 Metallo-β-lactamase. Molecules, 25(24), 5797.

Mahmod, I. I., Ismail, I. S., Alitheen, N. B., Normi, Y. M., Abas, F., Khatib, A., Rudiyanto, & Latip, J. (2020). NMR and LCMS analytical platforms exhibited the nephroprotective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity in the in vitro condition. BMC complementary medicine and therapies, 20(1), 320.

Oyeleye, A. O., Mohd Yusoff, S. F., Abd Rahim, I. N., Leow, A. T. C., Saidi, N. B., & Normi, Y. M. (2020). Effective refolding of a cysteine rich glycoside hydrolase family 19 recombinant chitinase from Streptomyces griseus by reverse dilution and affinity chromatography. PloS one, 15(10), e0241074.

Nezhad, N.G., Raja Abd Rahman, R.N.Z., Normi, Y.M., Oslan, S.N., Shariff, F.M., Leow, T.C. (2020) Integrative Structural and Computational Biology of Phytases for the Animal Feed Industry. Catalysts, 10, 844.

Mazalan, N.Z.S., Oyeleye, A., Rahman, R.N.Z.R.A., Aris, A. Z., Salleh, A. B., Normi, Y.M. (2020) Isolation and characterization of an acid and metal tolerant Enterobacter cloacae NZS strain from former mining lake in Selangor, Malaysia. Beni-Suef Univ J Basic Appl Sci 9, 27 (2020)

Oyeleye, A. & Normi, Y. M. (2018) Chitinase: diversity, limitations, and trends in engineering for suitable applications. Bioscience reports 38 (4), BSR2018032300 C

Ang, T. F., Salleh, A. B., Normi, Y. M. & Leow. T. C. (2018) In silico design of potentially functional artificial metallo-haloalkane dehalogenase containing catalytic zinc. 3Biotech 8(7), 314

Mohamed, R. A., Salleh, A. B., Leow ,T. C., Normi, Y. M., Abdul Rahman, M. B. (2018) Site-directed mutagenesis: role of lid region for T1 lipase specificity. Protein Engineering, Design and Selection 31(6), 221-229

Ang, T. F., Salleh, A. B., Normi, Y. M. & Leow, T. C. (2018) Dehalogenases: from improved performance to potential microbial dehalogenation applications. Molecules 23 (5), 1100

Ang, S. S., Salleh, A. B., Chor, A. L. T., Normi, Y. M., Tejo, B. A., Rahman, M. B. A. (2018) Biochemical Characterization of the Cytochrome P450 CYP107CB2 from Bacillus lehensis. The protein journal 37(2), 180-193

Malaysian Educational Module on Responsible Conduct of Research (2018) ISBN: 978-983-2915-37-91 Akademi Sains Malaysia, Malaysia

Mangavelu, A., Yahaya N. M.*, Leow, A. T. C., Ali, M. S. M., Rahman, R. N. Z. R. A (2017) CsoR Metalloregulatory Protein: Function, Mechanism and Relevance. The Pertanika Journal of Scholarly Research Reviews Vol. 2(3), 2016 eISSN: 2462-2028

Mohamed, R. A., Salleh, A. B., Leow, A. T. C., Yahaya, N.M., Rahman. M. B. A. (2017) Ability of T1 Lipase to Degrade Amorphous P(3HB): Structural and Functional Study. Molecular Biotechnology, 1-10

Maiangwa, J., Ali, M. S. M., Salleh, A. B., Rahman, R. N. Z. R. A., Normi, Y. M., Shariff, F.M. (2017) Lid opening and conformational stability of T1 Lipase is mediated by increasing chain length polar solvents PeerJ 5, e3341

Tan, S. H., Normi, Y. M., Leow, A. T. C., Salleh, A. B., Murad, A. M. A., Mahadi, N. M., Rahman, M. B. A. (2017) Danger lurking in the “unknowns”: structure-to-function studies of hypothetical protein Bleg1_2437 from Bacillus lehensis G1 alkaliphile revealed an evolutionary divergent B3 metallo-beta-lactamase. J Biochem (2017) 161(2): 167-186.

Ang, S. S., Salleh, A. B., Chor, A. L. T., Normi, Y. M., Tejo, B. A., Rahman, M. B. A. (2015) Molecular characterization, modeling and docking of CYP107CB2 from Bacillus lehensis G1, an alkaliphile. Computational Biology and Chemistry 2015, 56: 19-29

Ikram, N. K., Durrant, J. D., Muchtaridi, M., Zalaludin, A. S., Purwitasari, N., Mohamed, N., Rahim, A. S., Lam, C. K., Normi, Y.M., Rahman, N. A., Amaro, R. E., Wahab, H.A. (2015) A Virtual Screening Approach for Identifying Plants with Anti H5N1 Neuraminidase Activity. J Chem Inf Model. 2015, 55(2): 308-16

Foong, P. M., Karjiban, R. A., Normi, Y. M., Salleh, A. B., Rahman, M. B. A. (2015) Bioinformatics survey of the metal usage by psychrophilic yeast Glaciozyma antarctica PI12. Metallomics 2015, 7(1): 156-164

Tan, S. H., Normi, Y.M, Leow, A. T. C., Salleh, A.B., AbediKarjiban, R., Murad, A. M. A., Mahadi, N. M., Rahman, M. B. A. (2014) A Sco protein among the hypothetical proteins of Bacillus lehensis G1: Its 3D macromolecular structure and association with Cytochrome C Oxidase. BMC Structural Biology 2014, 14:11
Teh, B. A., Choi, S.B., Musa, N., Few, L.L., See Too, W.C., Salleh, A.B., Najimudin, N., Wahab, H.A., Normi, Y.M, (2014)
Structure to function prediction of hypothetical protein KPN_00953 (Ycbk) from Klebsiella pneumoniae MGH 78578 highlights possible role in cell wall metabolism. BMC Structural Biology 2014, 14:7

Bayat, S., Abdulmalek, E., Normi, Y.M,, Salleh, A. B., Tejo, A.B Rahman, M. B. A. (2014) Asymmetric aldol reactions catalyzed by the promiscuous aldo– ketoreductase enzyme, Tetrahedron Letters 2014, 55(46): 6303-
6306

Bayat, S., Tejo, B. A., Salleh, A.B., Abdulmalek, E., Normi, Y.M,, Rahman, M. B. A. (2014) Asymmetric Michael Reaction Catalyzed by Mimicked Peptides. Catalysis Letters 2013, 144: 222-228

Bayat, S., Tejo, B. A., Abdulmalek, E., Normi, Y.M,, Salleh, A. B., Rahman, M. B. A. (2013) Enantioselectivity Investigation of Short Polar Peptides with Different Positions in the Michael Reaction. Synthetic Communications 2013, 43(20): 2725-2732

Bayat, S., Tejo, B. A., Salleh, A.B., Abdulmalek, E., Normi, Y.M,, Rahman, M. B. A. (2013) Various Polar Tripeptides as Asymmetric Organocatalyst in Direct Aldol Reactions in Aqueous Media. Chirality 2013, 25(11): 726-734

Bayat, S., Abdulmalek, E., Tejo, B. A., Salleh, A.B., Normi, Y.M,, Rahman, M. B. A. (2013) Novel Octapeptide as an Asymmetric Catalyst for Michael Reaction in Aqueous Media. Synthetic Communications 2013, 43(23): 3130-
3140

Wong, M.T., Choi, S.B., Kuan, C.S., Chua, S.L., Chang, C.H., Normi, Y.M., See Too, W.C., Wahab, H.A., Few, L.L. (2012) Structural Modeling and Biochemical Characterization of Recombinant KPN_02809, a Zinc-Dependent Metalloprotease from Klebsiella pneumoniae MGH 78578. Int. J. Mol. Sci. 2012, 13, 901-917.

Choi, S. B., Normi, Y. M. & Wahab, H. A. (2011) Revealing the functionality of hypothetical protein KPN00728 from Klebsiella pneumoniae MGH78578: molecular dynamics simulation approaches. BMC Bioinformatics 2011, 12(Suppl 13):S11

Kuan, C.S,; Wong, M.T,; Choi, S.B.; Chang, C.C.; Yee, Y. H.; Wahab, H.A.; Normi, Y.M.; See Too, W.C.; Few, L.L. (2011) Klebsiella pneumonia yggG gene product: A Zinc-dependent Metalloprotease. Int. J. Mol. Sci. 2011, 12, 4441-4455.

Salleh Mohd Nor, Abhimanyu Veerakumarasivam, Normi Mohd Yahaya, Chen Jer Ming, Oh Pei Ching, Siti Najihah Abu Bakar, Nitia Educated, Inspired and Connected. The Malaysian Experience. ASM Lindau Programme 2010. Academy of Sciences Malaysia. (ISBN 978-983-9445-61-9)

Choi, S. B., Normi, Y. M. & Wahab, H. A. (2009) Why hypothetical protein KPN00728 of Klebsiella pneumoniae should be classified as Chain C of Succinate dehydrogenase? The Protein Journal, 28:415-427.

Normi, Y. M., Hiraishi, T., Taguchi, S., Abe, H., Sudesh, K., Najimudin, N. & Doi, Y. (2005) Characterization and properties of G4X mutants of Ralstonia eutropha PHA synthase for poly(3-hydroxybutyrate) biosynthesis in Escherichia coli. Macromol. Biosci. 5: 197-206.

Normi, Y. M., Hiraishi, T., Taguchi, S., Sudesh, K., Najimudin, N. & Doi, Y. (2005) Site-directed saturation mutagenesis at residue F420 and recombination with another beneficial mutation of Ralstonia
eutropha polyhydroxyalkanoate synthase. Biotechnol. Lett. 27: 705-712.

Hiraishi, T., Kikkawa, Y., Fujita, M., Normi, Y. M., Kanesato, M., Tsuge T., Sudesh, K., Maeda, M. and Doi, Y. (2005) AFM observation of in vitro polymerized poly[(R)-3-hydroxybutyrate]: insight into possible mechanism of PHB granule formation. Biomacromolecules 6:2671-2677. (IF = 5.788)

Tsuge, T., Saito, Y., Narike, M., Muneta, K., Normi, Y. M., Kikkawa, Y., Hiraishi, T. & Doi, Y. (2004) Mutation effects of a conserved alanine (Ala510) in type I polyhydroxyalkanoate synthase from Ralstonia eutropha on polyester biosynthesis. Macromol. Biosci. 4: 963-970.