PROFILE
Laman Web Staf UPM
YBHG. PROFESOR DR. LING KING HWA
KETUA JABATAN
JABATAN SAINS BIOPERUBATAN
lkh@upm.edu.my
PROFESIONAL
Maklumat profesional saya. Sila layari https://www.neurosains.org/ untuk sebarang maklumat lanjut.
NAMA :
(Ybhg. Profesor Dr.) LING KING HWA
JAWATAN PENTADBIRAN :
KETUA JABATAN
ENTITI :
JABATAN SAINS BIOPERUBATAN
JAWATAN HAKIKI :
PROFESOR
ENTITI :
FAKULTI PERUBATAN DAN SAINS KESIHATAN
DOWNLOAD CURRICULUM VITAE (PDF)
BIDANG PENYELIAAN
HUMAN GENETICS / MOLECULAR BIOLOGY AND GENETIC ENGINEERING / NEUROSCIENCE / STEM CELL / MOLECULAR MEDICINE
LATARBELAKANG PENDIDIKAN
2020
FELO PASCADOKTORAL (NEUROGENETIK) - 2016-2020
Harvard Medical School, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
2011
DOKTOR FALSAFAH (Neurogenetik) Kepujian, 2011
University of Adelaide, Australia.
University of Adelaide, Australia.
2005
MASTER SAINS, (Genetik) Kepujian, 2005
Universiti Putra Malaysia,
UPM Serdang, Selangor DE, Malaysia.
Universiti Putra Malaysia,
UPM Serdang, Selangor DE, Malaysia.
2003
SIJIL, Kepujian, 2003
S* Life Science Informatics Alliance,
S* Online Bioinformatics Course (http://www.s-star.org/)
S* Life Science Informatics Alliance,
S* Online Bioinformatics Course (http://www.s-star.org/)
2002
BACHELOR SAINS (Sains Bioperubatan) Kepujian, 2002
Universiti Putra Malaysia,
UPM Serdang, Selangor, MALAYSIA.
Universiti Putra Malaysia,
UPM Serdang, Selangor, MALAYSIA.
1998
Sijil Tinggi Pelajaran Malaysia (STPM), 1998
(Setara dengan A-Level)
Abdul Rahman Talib National Secondary School,
Kuantan, Pahang.
(Setara dengan A-Level)
Abdul Rahman Talib National Secondary School,
Kuantan, Pahang.
1996
SIJIL PELAJARAN MALAYSIA (SPM), 1996
(Setara dengan O-Level)
Alor Akar National Secondary School,
Kuantan, Pahang.
(Setara dengan O-Level)
Alor Akar National Secondary School,
Kuantan, Pahang.
PENGALAMAN KERJA
2005
Jun – Dec 2005
Pembantu Pengajar
S* Life Science Informatics Alliance,
S* Online Bioinformatics Course
Dihoskan oleh National University of Singapore, Singapore
(www.s-star.org)
Pembantu Pengajar
S* Life Science Informatics Alliance,
S* Online Bioinformatics Course
Dihoskan oleh National University of Singapore, Singapore
(www.s-star.org)
2004
2004 – sehingga kini
TUTOR DALAM BIDANG GENETIK & BIOINFORMATIK PERUBATAN,
Department of Obstetrics & Gynaecology,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang, Selangor DE.
TUTOR DALAM BIDANG GENETIK & BIOINFORMATIK PERUBATAN,
Department of Obstetrics & Gynaecology,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang, Selangor DE.
2002
2002 – 2004
Pembantu Penyelidik
Department of Human Growth and Development,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang, Selangor DE.
Pembantu Penyelidik
Department of Human Growth and Development,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang, Selangor DE.
1998
1998 – 1999
Guru Sementara
St Thomas National Secondary School,
Kuantan, Pahang DM.
Guru Sementara
St Thomas National Secondary School,
Kuantan, Pahang DM.
KURSUS DIHADIRI
2005
30th June – 4th July 2005 (Level: National)
Kursus Kenegaraan untuk Calon Master/PhD ke Luar Negara (KAO-H0994-05) anjuran Biro Tatanegara, Prime Minister Department, Malaysian Government. [Peserta]
Kursus Kenegaraan untuk Calon Master/PhD ke Luar Negara (KAO-H0994-05) anjuran Biro Tatanegara, Prime Minister Department, Malaysian Government. [Peserta]
PERSIDANGAN / BENGKEL / SEMINAR
2010
20-22hb Jan 2010
Attachment at Dr Carlos Portera-Cailliau’s laboratory at UCLA, USA. The attachment involved hands-on training on In Utero Electroporation (IUE) technique and was to learn how to surgically construct a cranial window on mouse.
Attachment at Dr Carlos Portera-Cailliau’s laboratory at UCLA, USA. The attachment involved hands-on training on In Utero Electroporation (IUE) technique and was to learn how to surgically construct a cranial window on mouse.
2006
4-8hb Sept 2006
8th Melbourne Bioinformatics Course organized by The Walter and Eliza Hall Institute, Melbourne, Victoria, Australia. [Peserta]
8th Melbourne Bioinformatics Course organized by The Walter and Eliza Hall Institute, Melbourne, Victoria, Australia. [Peserta]
2005
30hb Jun – 4hb July 2005
Malaysian Nationhood Course for Overseas Master/PhD Candidates (KAO-H0994-05) organized by the Biro Tatanegara, Prime Minister Department, Malaysian Government. [Peserta]
Malaysian Nationhood Course for Overseas Master/PhD Candidates (KAO-H0994-05) organized by the Biro Tatanegara, Prime Minister Department, Malaysian Government. [Peserta]
2005
22hb Feb – 5hb Mac 2005
Attachment at the Wellcome Trust Sanger Genome Institute (WTSGI), Hinxton and Institute for Animal Health (IAH), Compton, UK. [Latihan anotasi genom]
Attachment at the Wellcome Trust Sanger Genome Institute (WTSGI), Hinxton and Institute for Animal Health (IAH), Compton, UK. [Latihan anotasi genom]
2003
8-19hb Dis 2003
Workshop on "Genome Sequencing" at MTDC-UKM, Bangi, Selangor, Malaysia. [Fasilitator]
Workshop on "Genome Sequencing" at MTDC-UKM, Bangi, Selangor, Malaysia. [Fasilitator]
2003
6-7hb Oct 2003
Workshop on "gRNA – Genomics Research Network and Architecture" at MTDC-UKM, Bangi, Selangor, Malaysia. [Peserta]
Workshop on "gRNA – Genomics Research Network and Architecture" at MTDC-UKM, Bangi, Selangor, Malaysia. [Peserta]
2003
28hb July 2003
Training on "Statistical Methods for Experimental Research" organized by Faculty of Veterinary Medicine, UPM, Selangor, Malaysia, and UPM Veterinary Alumni. [Peserta]
Training on "Statistical Methods for Experimental Research" organized by Faculty of Veterinary Medicine, UPM, Selangor, Malaysia, and UPM Veterinary Alumni. [Peserta]
2003
8-11hb Jan 2003
Workshop on "Automated Sequencing: ABI PRISM 3730 Genetic Analyzer" at MTDC-UKM, Bangi, Selangor, Malaysia. [Peserta]
Workshop on "Automated Sequencing: ABI PRISM 3730 Genetic Analyzer" at MTDC-UKM, Bangi, Selangor, Malaysia. [Peserta]
2002
16-20hb Dis 2002
Workshop on "Genome Informatics" at MTDC-UKM, Bangi, Selangor, Malaysia. [Peserta]
Workshop on "Genome Informatics" at MTDC-UKM, Bangi, Selangor, Malaysia. [Peserta]
2002
5-9hb Aug 2002
Workshop on "Bioinformatics Tools for Molecular Biologist" at MTDC-UKM, Bangi, Selangor, Malaysia. [Peserta]
Workshop on "Bioinformatics Tools for Molecular Biologist" at MTDC-UKM, Bangi, Selangor, Malaysia. [Peserta]
2002
30-31hb Mei 2002
Workshop on "Automated Sequencing: ABI PRISM 377" at Faculty of Biotechnology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. [Peserta]
Workshop on "Automated Sequencing: ABI PRISM 377" at Faculty of Biotechnology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. [Peserta]
2002
15-19hb April 2002
Workshop on "Detection of Sequence Variants: Real-Time PCR and WAVEâ„¢ Technology" at CGAT, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia. [Peserta]
Workshop on "Detection of Sequence Variants: Real-Time PCR and WAVEâ„¢ Technology" at CGAT, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia. [Peserta]
2001
Mac-Mei 2001
Clinical laboratory training, Department of Pathology, Kuantan General Hospital,
Pahang, Malaysia.
Clinical laboratory training, Department of Pathology, Kuantan General Hospital,
Pahang, Malaysia.
PEMBENTANGAN KERTAS KERJA
2010
14-19hb Jan 2010
M1181: A novel miRNA involved in development of the mouse embryo. Keystone Symposia Conference, Colorado, USA. [Pembentang poster]
M1181: A novel miRNA involved in development of the mouse embryo. Keystone Symposia Conference, Colorado, USA. [Pembentang poster]
2009
15-17hb Nov 2009
Functional analysis of novel antisense transcripts at Sox4 gene locus during mouse cerebral corticogenesis. The Australian Society for Medical Research (ASMR) National Sci. Conference, Hobart, Tasmania, Australia. [Pembentang poster]
Functional analysis of novel antisense transcripts at Sox4 gene locus during mouse cerebral corticogenesis. The Australian Society for Medical Research (ASMR) National Sci. Conference, Hobart, Tasmania, Australia. [Pembentang poster]
2009
1hb Sept 2009
Discovery of a novel microRNA that may involve in early development of the mouse brain, neuronal differentiation and embryonic stem cell. FHS 2009 Postgraduate Research Expo, Adelaide, South Australia, Australia. [Pembentang poster]
Discovery of a novel microRNA that may involve in early development of the mouse brain, neuronal differentiation and embryonic stem cell. FHS 2009 Postgraduate Research Expo, Adelaide, South Australia, Australia. [Pembentang poster]
2009
2hb Jun 2009
Discovery of novel miRNAs in the developing mouse brain by in depth sequencing of small RNAs. The Australian Society for Medical Research, SA 2009 Scientific Meeting, Adelaide, South Australia, Australia. [Pembentang poster]
Discovery of novel miRNAs in the developing mouse brain by in depth sequencing of small RNAs. The Australian Society for Medical Research, SA 2009 Scientific Meeting, Adelaide, South Australia, Australia. [Pembentang poster]
2008
22hb Jul 2008
Global expression analysis revealed spatio-temporal regulation and genomic clustering of Sox4 sense-antisense transcripts during cerebral corticogenesis in the mouse. FHS 2008 Postgraduate Research Expo, SA, Australia. [Pembentang poster]
Global expression analysis revealed spatio-temporal regulation and genomic clustering of Sox4 sense-antisense transcripts during cerebral corticogenesis in the mouse. FHS 2008 Postgraduate Research Expo, SA, Australia. [Pembentang poster]
2008
17-21hb Feb 2008
Global expression analysis of the developing mouse cerebral cortex reveals spatio-temporal regulation of sense and antisense expressions. 29th Lorne Genome Conference, Victoria, Australia. [Pembentang poster]
Global expression analysis of the developing mouse cerebral cortex reveals spatio-temporal regulation of sense and antisense expressions. 29th Lorne Genome Conference, Victoria, Australia. [Pembentang poster]
2007
5hb Jul 2007
High-throughput validation of mouse brain expression data using Roche Universal Probe Library (UPL) and LC480 real time PCR instrument. Genomic Disorder Research Centre Seminar Series, Melbourne University. [Pembentang Undangan]
High-throughput validation of mouse brain expression data using Roche Universal Probe Library (UPL) and LC480 real time PCR instrument. Genomic Disorder Research Centre Seminar Series, Melbourne University. [Pembentang Undangan]
2007
12-17hb Jul 2007
Global expression analysis and identification of novel regulatory networks during cortical development in mouse. The IBRO World Congress of Neuroscience, Victoria, Australia. [Pembentang poster]
Global expression analysis and identification of novel regulatory networks during cortical development in mouse. The IBRO World Congress of Neuroscience, Victoria, Australia. [Pembentang poster]
2007
5-7hb Mei 2007
A single nucleotide polymorphism of the human fatty acid amide hydrolase gene (FAAH): Risk of drug addiction in Malaysian subjects. The 7th National Congress on Genetics, Kelantan, Malaysia. [Pengarang bersama poster]
A single nucleotide polymorphism of the human fatty acid amide hydrolase gene (FAAH): Risk of drug addiction in Malaysian subjects. The 7th National Congress on Genetics, Kelantan, Malaysia. [Pengarang bersama poster]
2006
26hb Nov-1hb Dic 2006
Neuropathology and global gene expression in Ts1Cje, a mouse model of Down syndrome. The 3rd Australian Health and Medical Research Congress (AH&MRC),Victoria, Australia. [Pengarang bersama poster]
Neuropathology and global gene expression in Ts1Cje, a mouse model of Down syndrome. The 3rd Australian Health and Medical Research Congress (AH&MRC),Victoria, Australia. [Pengarang bersama poster]
2005
29hb April 2005
Sequencing, assembly and analysis of chromosome one of Eimeria tenella. Sequencing Workshop, National Genome Institute, Malaysia. [Pembentang Undangan]
Sequencing, assembly and analysis of chromosome one of Eimeria tenella. Sequencing Workshop, National Genome Institute, Malaysia. [Pembentang Undangan]
2005
4-5hb April 2005
Sequencing and analysis of chromosome one of Eimeria tenella. 15th Malaysian Society for Molecular Biology and Biotechnology (MSMBB), Berjaya Times Square Hotel, Kuala Lumpur. {Pembentang Undangan]
Sequencing and analysis of chromosome one of Eimeria tenella. 15th Malaysian Society for Molecular Biology and Biotechnology (MSMBB), Berjaya Times Square Hotel, Kuala Lumpur. {Pembentang Undangan]
2005
24-25hb Feb 2005
Assembly, finishing and sequence analysis of chromosome one of Eimeria tenella. 3rd Eimeria Genome Consortium Meeting, Wellcome Trust Sanger Genome Institute, Hinxton, United Kingdom. [Pembentang oral]
Assembly, finishing and sequence analysis of chromosome one of Eimeria tenella. 3rd Eimeria Genome Consortium Meeting, Wellcome Trust Sanger Genome Institute, Hinxton, United Kingdom. [Pembentang oral]
2004
20-21hb Dis 2004
High-throughput sequencing and analysis of chromosome one of Eimeria tenella. The 4th Annual Seminar for National Science Fellowship 2004, jointly organized by the MOSTI and USM, Pulau Pinang, Malaysia. [Pembentang oral]
High-throughput sequencing and analysis of chromosome one of Eimeria tenella. The 4th Annual Seminar for National Science Fellowship 2004, jointly organized by the MOSTI and USM, Pulau Pinang, Malaysia. [Pembentang oral]
2004
8-10hb Jan 2004
Sequencing analysis of chromosome one of Eimeria tenella. 2nd Annual Microbial Genomics Top-Down Projects Meeting, Pan Pacific Hotel, Pangkor Island. [Pembentang oral]
Sequencing analysis of chromosome one of Eimeria tenella. 2nd Annual Microbial Genomics Top-Down Projects Meeting, Pan Pacific Hotel, Pangkor Island. [Pembentang oral]
2003
12-25hb Mei 2003
High-throughput sequencing of chromosome one of Eimeria tenella. Eimeria Genome Consortium Meeting at Institute of Animal Health, Compton, United Kingdom. [Pembentang oral]
High-throughput sequencing of chromosome one of Eimeria tenella. Eimeria Genome Consortium Meeting at Institute of Animal Health, Compton, United Kingdom. [Pembentang oral]
2003
3-5hb Dis 2003
GAP4: Multiple Integrated Assemblies – Toward the generation of a complete sequence of chromosome one of Eimeria tenella. 8th Biological Sciences Graduate Congress, National University of Singapore, Singapore. [Pembentang poster]
GAP4: Multiple Integrated Assemblies – Toward the generation of a complete sequence of chromosome one of Eimeria tenella. 8th Biological Sciences Graduate Congress, National University of Singapore, Singapore. [Pembentang poster]
2003
8-10hb Sept 2003
A survey of repetitive elements in chromosome one and two of Eimeria tenella. International Conference on Bioinformatics, Penang, Malaysia. [Pengarang bersama poster]
A survey of repetitive elements in chromosome one and two of Eimeria tenella. International Conference on Bioinformatics, Penang, Malaysia. [Pengarang bersama poster]
2003
8-10hb Sept 2003
The assembly and generation of a draft sequence for chromosome one of Eimeria tenella. International Conference on Bioinformatics, Penang, Malaysia. [Pembentang poster]
The assembly and generation of a draft sequence for chromosome one of Eimeria tenella. International Conference on Bioinformatics, Penang, Malaysia. [Pembentang poster]
2003
12hb Ogos 2003
A survey of DNA repeats in chromosome one and two of Eimeria tenella. 28th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Putrajaya, Malaysia. [Pengarang bersama poster]
A survey of DNA repeats in chromosome one and two of Eimeria tenella. 28th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Putrajaya, Malaysia. [Pengarang bersama poster]
2003
12hb Aug 2003
Detection of the angiotensinogen gene M235T variant and its association with essential hypertension and plasma renin activity in Malaysian subjects. 28th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology,
Detection of the angiotensinogen gene M235T variant and its association with essential hypertension and plasma renin activity in Malaysian subjects. 28th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology,
2003
2-6th Jul 2003
The angiotensinogen M235T gene Variants and its association with essential hypertension and plasma renin activity in Malaysian subjects. 7th International Symposium on Mutations in the Genome. Palm Cov. Australia. [Pengarang bersama post
The angiotensinogen M235T gene Variants and its association with essential hypertension and plasma renin activity in Malaysian subjects. 7th International Symposium on Mutations in the Genome. Palm Cov. Australia. [Pengarang bersama post
2003
8-10hb Jun 2003
High-throughput sequencing of chromosome one of Eimeria tenella for gene discoveries. Universiti Putra Malaysia 2003 R&D Exhibition, PKSSAAS Hall, Universiti Putra Malaysia, Selangor, Malaysia. [Pembentang poster]
High-throughput sequencing of chromosome one of Eimeria tenella for gene discoveries. Universiti Putra Malaysia 2003 R&D Exhibition, PKSSAAS Hall, Universiti Putra Malaysia, Selangor, Malaysia. [Pembentang poster]
2002
22-24hb Mei 2002
The prevalence of MTHFR677C-T missense mutation, total homocysteine levels and associated risk factors in Malay subjects. Young Researcher awards for MSMBB, Selangor. [Pembentang oral]
The prevalence of MTHFR677C-T missense mutation, total homocysteine levels and associated risk factors in Malay subjects. Young Researcher awards for MSMBB, Selangor. [Pembentang oral]
PENGAJARAN
2010
Human Genetics Module (SPP3251) - Program MD.
2010
Medical Genetics (HGD5502) - Postgrad. MSc/PhD
2010
Gene Expression Module (SPP3241) - MD programme.
ANUGERAH DAN PENCAPAIAN
2009
Best Poster Presentation Award – SA, Australia level, 2009
The Australian Society for Medical Research.
The Australian Society for Medical Research.
2009
Discipline of Medicine Travelling Fund, UoA, 2009 – AUD500.00
To Keystone Symposia Conference in Colorado, USA.
To Keystone Symposia Conference in Colorado, USA.
2009
FHS Postgraduate Travelling Fellowship Award, UoA, 2009 – AUD1500.00
To Keystone Symposia Conference in Colorado, USA.
To Keystone Symposia Conference in Colorado, USA.
2008
AFSI equivalent – International Level, 2008 - 2010
Adelaide Fees Scholarship International for pursuing PhD degree in The University of Adelaide, Adelaide, Australia.
Adelaide Fees Scholarship International for pursuing PhD degree in The University of Adelaide, Adelaide, Australia.
2007
Marquis Who’s Who in the World 2007 – International Level, 2007
Listed biographee in Marquis Who’s Who in the World 2007 edition.
Listed biographee in Marquis Who’s Who in the World 2007 edition.
2006
UPM Scholarship – University Level, 2006 - 2009
Universiti Putra Malaysia Staff Training Scholarship for pursuing PhD degree in The University of Melbourne, Victoria, Australia.
Universiti Putra Malaysia Staff Training Scholarship for pursuing PhD degree in The University of Melbourne, Victoria, Australia.
2006
MIFRS Scholarship – International Level, 2006 - 2008
Melbourne International Fee Remission Scholarship for pursuing PhD degree in The University of Melbourne, Victoria, Australia.
Melbourne International Fee Remission Scholarship for pursuing PhD degree in The University of Melbourne, Victoria, Australia.
2006
Excellence Service Award – University Level, 2006
For excellence service provided in the year 2006 at the Faculty of Medicine and Health Sciences, Universiti Putra Malaysia.
For excellence service provided in the year 2006 at the Faculty of Medicine and Health Sciences, Universiti Putra Malaysia.
2004
Gold Prize – National Level, 2004
For the best oral presentation (Biotechnology Section)
4th Annual Seminar for National Science Fellowship 2004
Ling KH, Rosli R, Shamsudin MN, Mohamed R, Wan KL. High-throughput sequencing and analysis of chrom
For the best oral presentation (Biotechnology Section)
4th Annual Seminar for National Science Fellowship 2004
Ling KH, Rosli R, Shamsudin MN, Mohamed R, Wan KL. High-throughput sequencing and analysis of chrom
2003
Silver Medal Award – University Level, 2003
UPM 2003 Research & Development Exhibition.
UPM 2003 Research & Development Exhibition.
2003
Best Poster Presentation Award – National Level, 2003
The Malaysian Society for Biochemistry and Molecular Biology (MSBMB).
The Malaysian Society for Biochemistry and Molecular Biology (MSBMB).
2003
Certificate of Appreciation – National Level, 2003
For the contribution to the rapid genome sequencing, assembly and analysis of two coronavirus genomes.
By The Ministry of Science, Technology and Environment.
For the contribution to the rapid genome sequencing, assembly and analysis of two coronavirus genomes.
By The Ministry of Science, Technology and Environment.
2002
National Science Fellowship (NSF) – National Level, 2002 – 2004
Ministry of Science, Technology and Environment, Malaysia.
Ministry of Science, Technology and Environment, Malaysia.
1996
Excellent Award for Sijil Pelajaran Malaysia – School Level, 1996
For Excellent Achievement in Science
Alor Akar National Type Secondary School, Kuantan, Pahang DM, Malaysia.
For Excellent Achievement in Science
Alor Akar National Type Secondary School, Kuantan, Pahang DM, Malaysia.
1996
Model Student Award – School Level, 1996
Alor Akar National Type Secondary School,
Kuantan, Pahang DM, Malaysia.
Alor Akar National Type Secondary School,
Kuantan, Pahang DM, Malaysia.
1996
Excellent Award for Sijil Pelajaran Malaysia – State Level, 1996
For Excellent SPM Achievement
Pahang State Foundation, Malaysia.
For Excellent SPM Achievement
Pahang State Foundation, Malaysia.
BIDANG PENGKHUSUSAN
Transkriptomik dan Genomik
Genetik Perkembangan Neuro
BIDANG PENYELIDIKAN
Role of Sox4 sense and antisense transcripts in brain and cancer development.
Discovery of new genes/transcripts/small RNAs during mammalian or disease development.
The biology and genetics of long non-coding RNA during mammalian development.
PENERBITAN
2025
The Interplay of Inflammation and Gut-Microbiota Dysbiosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
2025
The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes
2025
The Regulatory Roles of REST in the Synaptic Development,Function and Related Neurological Disorders
2025
Transient prenatal ruxolitinib treatment promotes neurogenesis and suppresses astrogliogenesis during embryonic mouse brain development
2025
Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome
2025
Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis
2024
Reduced REST Expression in Neural Progenitor Cells, Adult Cortex, and Impaired REST Nuclear Translocation in the Prefrontal Cortex of Ts1Cje Mouse Model of Down Syndrome
2024
Brain Insulin Resistance in Down Syndrome: Involvement of PI3K-Akt/mTor Axis in Early-Onset of Alzheimer's Disease and Its Potential as A Therapeutic Target
2024
Chromosomal and cellular therapeutic approaches for Down syndrome: A research update
2023
Reduced REST expression in neural progenitor cells, adult cortex, and impaired REST nuclear translocation in the prefrontal cortex of Ts1Cje mouse model of Down syndrome
2023
Impaired neural stress resistance and loss of REST in bipolar disorder
2023
Mitochondria dysfunction and bipolar disorder: from pathology to therapy
2023
REST Targets JAK–STAT and HIF-1 Signaling Pathways in Human Down Syndrome Brain and Neural Cells
2022
Mesenchymal Stromal Cells?Derived Exosome and the Roles in the Treatment of Traumatic Brain Injury
2022
Signature pattern of gene expression and signaling pathway in premature diabetic patients uncover their correlation to early age coronary heart disease
2021
The expression profile of miR-3099 during neural development of Ts1Cje mouse model of Down syndrome
2021
Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses
2021
Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
2021
Transient prenatal ruxolitinib treatment suppresses astrogenesis during development and improves learning and memory in adult mice
2021
Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy
2020
Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells
2020
Development and Differentiation of Midbrain Dopaminergic Neuron: From Bench to Bedside
2020
Single nucleotide polymorphism of BDNF Val66Met (rs6265) and its association to neuropsychiatric disorders
2020
BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder.
2019
Antitumor effects of berberine against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 breast cancer cells using molecular modelling and in vitro study
2019
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease
2019
Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects
2019
Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients
2019
Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model
2019
EXPRESSION PROFILING OF NOTCH SIGNALLING PATHWAY AND GAMMASECRETASE ACTIVITY IN THE BRAIN OF TS1CJE MOUSE MODEL OF DOWN SYNDROME
2019
Mitragynine (Kratom) impairs spatial learning and hippocampal synaptic transmission in rats
2019
miR-3099 promotes neurogenesis and inhibits astrogliogenesis during murine neural development
2018
Development and validation of high resolution melting assays for high-throughput Screening of BDNF rs6265 and DAT1 rs40184
2018
Pathogenic mutations in ARX, CDKL5 and STXBP1 genes are not associated with the early-onset epileptic encephalopathy in Malaysian pediatric patients: A pilot study
2018
Transcriptomic profiling of skeletal muscle from the Ts1Cje mouse model of Down syndrome suggests dysregulation of trisomic genes associated with neuromuscular junction signaling, oxidative stress and chronic inflammation
2018
Construction and Validation of a Mammalian Expression Vector for in Utero Electroporation Study of miR-3099 in the Mouse Neocortex
2017
In silico prediction and validation of Gfap as miR-3099 target in the mouse brain
2017
Molecular Modelling of Berberine Derivatives as Inhibitors of Human Smoothened Receptor and Hedgehog Signalling Pathway Using a Newly Developed Algorithm on Anti-Cancer Drugs
2016
Impulse control behaviours in a Malaysian Parkinson?s disease population
2016
Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in Down syndrome brain
2016
In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts
2016
Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain
2015
DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson?s disease patients
2014
Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
2014
MiR-3099 is Overexpressed in Differentiating 46c Mouse Embryonic Stem Cells upon Neural Induction
2013
MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome
2012
Genome-wide gene expression profiling identifies overlap with malignant adrenocortical tumours and novel mechanisms of inefficient steroidogenesis in familial ACTH-independent macronodular adrenal hyperplasia
2010
Robust, Reversible Gene Knockdown Using a Single Lentiviral Short Hairpin RNA Vector
2010
Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome.
2009
Familial vasopressin-sensitive ACTH-independent macronodular adrenal hyperplasia (VPs-AIMAH): clinical studies of three kindreds