PROFILE
UPM's Staff Profile
YBHG. PROFESOR DR. JOHNSON A/L STANSLAS
PROFESSOR
FACULTY OF MEDICINE AND HEALTH SCIENCES
rcxjs@upm.edu.my
PROFESSIONAL
NAME :
(Ybhg. Profesor Dr.) JOHNSON A/L STANSLAS
POST :
PROFESSOR
ENTITY :
FACULTY OF MEDICINE AND HEALTH SCIENCES
FIELD OF SUPERVISION
CANCER BIOLOGY AND ONCOLOGY / MEDICAL SCIENCES / NEUROSCIENCE / PHARMACOLOGY / TOXICOLOGY
PUBLICATION
2024
An Andrographis paniculata Burm. Nees extract standardized for three main Andrographolides prevents house dust mite-induced airway inflammation, remodeling, and hyperreactivity by regulating Th1/Th2 gene expression in mice
2024
Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment
2024
Advances in psoriasis research: From pathogenesis to therapeutics
2024
The new paradigm in animal testing – “3Rs alternatives”
2024
Estrogenic Post-Menopausal Anti-Osteoporotic Mechanism of Achyranthes aspera L.: Phytochemicals and Network Pharmacology Approaches
2023
Challenges and Strategies for Improving Access to Cancer Drugs in Malaysia: Summary of Opinions Expressed at the 2nd MACR International Scientific Conference 2022
2023
Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species: Inhibition of Nucleic Acid Synthesis
2023
Lignosus rhinocerotis extract ameliorates airway inflammation and remodelling via attenuation of TGF-?1 and Activin A in a prolonged induced allergic asthma model
2023
More than just a KRAS inhibitor: DCAI abrogates the self-renewal of pancreatic cancer stem cells in vitro
2023
Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment
2022
Adaptive therapy to circumvent drug resistance to tyrosine kinase inhibitors in cancer: is it clinically relevant?
2022
The impact of cycleanine in cancer research: a computational study
2022
Pancreatic cancer treatment with targeted therapies: Are we there yet?
2022
A Preliminary Nuclear Magnetic Resonance Metabolomics Study Identifies Metabolites that Could Serve as Diagnostic Markers of Major Depressive Disorder
2022
Delaying Emergence of Resistance to KRAS Inhibitors with Adaptive Therapy:
2022
Molecular and immunomodulatory actions of new antiasthmatic agents: Exploring the diversity of biologics in Th2 endotype asthma
2022
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment
2021
Biological and Pharmacogenomics Bases of Gastrointestinal and Some Long-term Selective Serotonin Reuptake Inhibitors-induced Adverse Effects
2021
Peptide-based and small molecule PD-1 and PD-L1 pharmacological modulators in the treatment of cancer
2021
Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines
2021
Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma
2021
Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines
2021
Serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic Malay patients with first episode of major depressive disorder
2020
An Application of pET SUMO Protein Expression System in Escherichia coli: Cloning, Expression, Purification, and Characterisation of Native Kras4BG12V Oncoprotein
2020
Influence of N6-benzyladenine and sucrose on In Vitro direct regeneration and microrhizome induction of Kaempferia parviflora wall. Ex baker, an important ethnomedicinal herb of Asia
2020
Biosynthesis of Quercetin Palmitate Esters and Evaluation of their Physico-Chemical Properties and Stability
2020
In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein
2019
Oestrogenic activity of mimosine on MCF-7 breast cancer cell line through the ER?-mediated pathway
2019
Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
2019
Genetic endophenotypes for insomnia of major depressive disorder and treatment-induced insomnia
2019
A standardised Andrographis paniculata Burm. Nees aqueous extract prevents Lipopolysaccharide-induced cognitive deficits through suppression of inflammatory cytokines and oxidative stress mediators
2018
Breaking Dormancy and Effects of Shade Level and NPK Fertilizer Rates on Yield of Zingiber zerumbet (L.) Smith (Lempoyang)
2018
Association of Allelic Interaction of Single Nucleotide Polymorphisms of Influx and Efflux Transporters Genes With Nonhematologic Adverse Events of Docetaxel in Breast Cancer Patient
2018
Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
2018
Morphological and molecular datasets for Kaempferia species
2018
Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction(
2018
Identification of ethnomedicinally important Kaempferia L. (Zingiberaceae) species based on morphological traits and suitable DNA region
2017
Estimation of Oxygen Diffusing Conductance in Different Dissection Portion of the Placental Cotyledon of Passive Smoking Mothers
2017
Plasma alpha-1- acid glycoprotein as a potential predictive biomarker of non-haematological adverse events of docetaxel in breast cancer patients.
2017
Enzymatic synthesis of quercetin oleate esters using Candida antarctica lipase B
2017
In vivo study of tetraprenyltoluquinone, an anticancer compounds from garcinia cowa roxb
2016
A semisynthetic diterpenoid lactone inhibits NF-kB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model
2016
Enzymatic synthesis of quercetin oleate esters using Candida antarctica lipase B
2016
SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy
2016
Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation
2016
Lipase-catalyzed acylation of quercetin with cinnamic acid
2016
Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs
2016
Cytotoxic properties and complete nuclear magnetic resonance assignment of isolated xanthones from the root of Garcinia cowa Roxb
2015
Tetraprenyltoluquinone, an Anticancer Compound from Garcinia cowa Roxb Induce Cell Cycle Arrest on H460 Non Small Lung Cancer Cell Line
2015
CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145
2015
SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line
2014
In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog
2014
Ethnobotanical, phytochemical, pharmacological, and toxicological aspects of persicaria hydropiper (L.) delarbre
2014
Bioactivity-Guided Isolation of Anticancer Agents from Bauhinia kockiana Korth
2014
NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide
2014
SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells
2013
Molecular targets in the discovery and development of novel antimetastatic agents: Current progress and future prospects
2013
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
2012
Estrogenic activity of selected Myrsinaceae species in MCF-7 human breast cancer cells
2012
Pharmacogenetics of taxanes: impact of gene polymorphisms of drug transporters on pharmacokinetics and toxicity
2012
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer
2011
Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells
2011
Assessment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia
2011
Isolation and cytotoxicity of triterpenes from the roots of Phyllanthus pulcher Wall. ex Mull. Arg. (Euphorbiaceae)
2009
Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis
2009
Cytotoxic and nitric oxide inhibitory activities of methanol extracts of Garcinia species
2008
Modelling of chromatin morphologies in breast cancer cells undergoing apoptosis using generalized Cauchy field
2008
Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 and apoptosis.
2008
Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients