PROFILE
UPM's Staff Profile
YBHG. PROFESOR DR. JOHNSON A/L STANSLAS
PROFESSOR
FACULTY OF MEDICINE AND HEALTH SCIENCES
rcxjs@upm.edu.my
NAME:
(YBHG. PROFESOR DR.) JOHNSON A/L STANSLAS
POSITION:
PROFESSOR
ENTITY:
FACULTY OF MEDICINE AND HEALTH SCIENCES
FIELDS OF SUPERVISION
Cancer Biology And Oncology / Medical Sciences / Neuroscience / Pharmacology / Toxicology
PUBLICATION
2024:
An Andrographis paniculata Burm. Nees extract standardized for three main Andrographolides prevents house dust mite-induced airway inflammation, remodeling, and hyperreactivity by regulating Th1/Th2 gene expression in mice
2024:
Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment
2024:
Advances in psoriasis research: From pathogenesis to therapeutics
2024:
The new paradigm in animal testing – “3Rs alternatives”
2024:
Estrogenic Post-Menopausal Anti-Osteoporotic Mechanism of Achyranthes aspera L.: Phytochemicals and Network Pharmacology Approaches
2023:
Challenges and Strategies for Improving Access to Cancer Drugs in Malaysia: Summary of Opinions Expressed at the 2nd MACR International Scientific Conference 2022
2023:
Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species: Inhibition of Nucleic Acid Synthesis
2023:
Lignosus rhinocerotis extract ameliorates airway inflammation and remodelling via attenuation of TGF-?1 and Activin A in a prolonged induced allergic asthma model
2023:
More than just a KRAS inhibitor: DCAI abrogates the self-renewal of pancreatic cancer stem cells in vitro
2023:
Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment
2022:
Adaptive therapy to circumvent drug resistance to tyrosine kinase inhibitors in cancer: is it clinically relevant?
2022:
The impact of cycleanine in cancer research: a computational study
2022:
Pancreatic cancer treatment with targeted therapies: Are we there yet?
2022:
A Preliminary Nuclear Magnetic Resonance Metabolomics Study Identifies Metabolites that Could Serve as Diagnostic Markers of Major Depressive Disorder
2022:
Delaying Emergence of Resistance to KRAS Inhibitors with Adaptive Therapy:
2022:
Molecular and immunomodulatory actions of new antiasthmatic agents: Exploring the diversity of biologics in Th2 endotype asthma
2022:
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment
2021:
Biological and Pharmacogenomics Bases of Gastrointestinal and Some Long-term Selective Serotonin Reuptake Inhibitors-induced Adverse Effects
2021:
Peptide-based and small molecule PD-1 and PD-L1 pharmacological modulators in the treatment of cancer
2021:
Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines
2021:
Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma
2021:
Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines
2021:
Serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic Malay patients with first episode of major depressive disorder
2020:
An Application of pET SUMO Protein Expression System in Escherichia coli: Cloning, Expression, Purification, and Characterisation of Native Kras4BG12V Oncoprotein
2020:
Influence of N6-benzyladenine and sucrose on In Vitro direct regeneration and microrhizome induction of Kaempferia parviflora wall. Ex baker, an important ethnomedicinal herb of Asia
2020:
Biosynthesis of Quercetin Palmitate Esters and Evaluation of their Physico-Chemical Properties and Stability
2020:
In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein
2019:
Oestrogenic activity of mimosine on MCF-7 breast cancer cell line through the ER?-mediated pathway
2019:
Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
2019:
Genetic endophenotypes for insomnia of major depressive disorder and treatment-induced insomnia
2019:
A standardised Andrographis paniculata Burm. Nees aqueous extract prevents Lipopolysaccharide-induced cognitive deficits through suppression of inflammatory cytokines and oxidative stress mediators
2018:
Breaking Dormancy and Effects of Shade Level and NPK Fertilizer Rates on Yield of Zingiber zerumbet (L.) Smith (Lempoyang)
2018:
Association of Allelic Interaction of Single Nucleotide Polymorphisms of Influx and Efflux Transporters Genes With Nonhematologic Adverse Events of Docetaxel in Breast Cancer Patient
2018:
Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
2018:
Morphological and molecular datasets for Kaempferia species
2018:
Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction(
2018:
Identification of ethnomedicinally important Kaempferia L. (Zingiberaceae) species based on morphological traits and suitable DNA region
2017:
Estimation of Oxygen Diffusing Conductance in Different Dissection Portion of the Placental Cotyledon of Passive Smoking Mothers
2017:
Plasma alpha-1- acid glycoprotein as a potential predictive biomarker of non-haematological adverse events of docetaxel in breast cancer patients.
2017:
Enzymatic synthesis of quercetin oleate esters using Candida antarctica lipase B
2017:
In vivo study of tetraprenyltoluquinone, an anticancer compounds from garcinia cowa roxb
2016:
A semisynthetic diterpenoid lactone inhibits NF-kB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model
2016:
Enzymatic synthesis of quercetin oleate esters using Candida antarctica lipase B
2016:
SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy
2016:
Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation
2016:
Lipase-catalyzed acylation of quercetin with cinnamic acid
2016:
Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs
2016:
Cytotoxic properties and complete nuclear magnetic resonance assignment of isolated xanthones from the root of Garcinia cowa Roxb
2015:
Tetraprenyltoluquinone, an Anticancer Compound from Garcinia cowa Roxb Induce Cell Cycle Arrest on H460 Non Small Lung Cancer Cell Line
2015:
CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145
2015:
SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line
2014:
In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog
2014:
Ethnobotanical, phytochemical, pharmacological, and toxicological aspects of persicaria hydropiper (L.) delarbre
2014:
Bioactivity-Guided Isolation of Anticancer Agents from Bauhinia kockiana Korth
2014:
NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide
2014:
SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells
2013:
Molecular targets in the discovery and development of novel antimetastatic agents: Current progress and future prospects
2013:
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
2012:
Estrogenic activity of selected Myrsinaceae species in MCF-7 human breast cancer cells
2012:
Pharmacogenetics of taxanes: impact of gene polymorphisms of drug transporters on pharmacokinetics and toxicity
2012:
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer
2011:
Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells
2011:
Assessment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia
2011:
Isolation and cytotoxicity of triterpenes from the roots of Phyllanthus pulcher Wall. ex Mull. Arg. (Euphorbiaceae)
2009:
Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis
2009:
Cytotoxic and nitric oxide inhibitory activities of methanol extracts of Garcinia species
2008:
Modelling of chromatin morphologies in breast cancer cells undergoing apoptosis using generalized Cauchy field
2008:
Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 and apoptosis.
2008:
Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients